DIF-3( —— )

Catalog No. M35425 CAS No. 113411-17-9

DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins.

Purity : >98% (HPLC)

COA

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HNMR

HPLC

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Biological Information

Product Name

DIF-3
Note

Research use only, not for human use.
Brief Description

DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins.
Description

DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Wnt/Notch/Hedgehog
Target

Wnt/beta/catenin
Recptor

Wnt/beta-catenin | GSK-3 | CDK
Research Area

——
Indication

——

Chemical Information

CAS Number

113411-17-9
Formula Weight

272.72
Molecular Formula

C13H17ClO4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (366.68 mM; Ultrasonic )
SMILES

CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Naoya Kubokura , et al. Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. J Pharmacol Sci. 2015 Apr;127(4):446-55.?

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