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DHODH-IN-1

CAS No. 1800296-63-2

DHODH-IN-1( —— )

Catalog No. M26153 CAS No. 1800296-63-2

DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DHODH-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM.
  • Description
    DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.(In Vitro):DHODH-IN-1 (4-100 nM) prevents the measles virus from replicating in cells. When transfecting cells with ssRNA molecules, DHODH-IN-1 (0.008-5 μM) can increase the expression of ISRE luciferase reporter gene. DHODH-IN-1 inhibits Jurkat cell proliferation with an IC50 value of 0.02 μM.(In Vivo):The t1/2 for DHODH-IN-1 is 27–41 min.
  • In Vitro
    DHODH-IN-1 (compound 18d) strongly inhibits Jurkat cells proliferation (IC50=0.02 μM). DHODH-IN-1 (4, 20, 100 nM) blocks the measles virus replication in cells. DHODH-IN-1 (0.008, 0.04, 0.2, 1, 5 μM) increases the expression of an ISRE-luciferase reporter gene when transfecting cells with ssRNA molecules. Cell Proliferation Assay Cell Line:Jurkat cells Concentration:0.00001, 0.0001, 0.001, 0.01, 0.1, 1, 10 μM Incubation Time:72 hours Result:Strongly inhibited Jurkat cells proliferation (IC50=0.02 μM).
  • In Vivo
    DHODH-IN-1 (compound 18d) has a t1/2 of 27–41 min.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    N-acylethanolamine acid amidase (NAAA)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1800296-63-2
  • Formula Weight
    403.405
  • Molecular Formula
    C21H20F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)Oc1nn(c(C)c1Oc1c(F)cccc1F)-c1ncc(cc1F)C1CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yannick Fotio, et al. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl)-[(2S)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 Aug;378(2):70-76.
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