DC661

CAS No. 1872387-43-3

DC661( DC-661 | DC 661 )

Catalog No. M12900 CAS No. 1872387-43-3

DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 96 In Stock
5MG 178 In Stock
10MG 302 In Stock
25MG 516 In Stock
50MG 740 In Stock
100MG 1017 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    DC661
  • Note
    Research use only, not for human use.
  • Brief Description
    DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).
  • Description
    DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1); inhibits autophagy and causes significant impairment of tumor growth.
  • In Vitro
    DC661 (0.1 and 10 μM) accumulates autophagic vesicles in melanoma cells.
  • In Vivo
    ——
  • Synonyms
    DC-661 | DC 661
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1872387-43-3
  • Formula Weight
    550.612
  • Molecular Formula
    C33H41Cl2N3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 62.5 mg/mL 113.11 mM;H2O : < 0.1 mg/mL
  • SMILES
    CN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34
  • Chemical Name
    N1-(6-chloronaphthalen-1-yl)-N6-(6-((6-chloronaphthalen-1-yl)amino)hexyl)-N6-methylhexane-1,6-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rebecca VW, et al. Cancer Discov. 2018 Nov 15. pii: CD-18-0706. doi: 10.1158/2159-8290.CD-18-0706.
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