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DC661

CAS No. 1872387-43-3

DC661( DC-661 | DC 661 )

Catalog No. M12900 CAS No. 1872387-43-3

DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DC661
  • Note
    Research use only, not for human use.
  • Brief Description
    DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).
  • Description
    DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1); inhibits autophagy and causes significant impairment of tumor growth.
  • In Vitro
    DC661 (0.1 and 10 μM) accumulates autophagic vesicles in melanoma cells.
  • In Vivo
    ——
  • Synonyms
    DC-661 | DC 661
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1872387-43-3
  • Formula Weight
    550.612
  • Molecular Formula
    C33H41Cl2N3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 62.5 mg/mL 113.11 mM;H2O : < 0.1 mg/mL
  • SMILES
    CN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34
  • Chemical Name
    N1-(6-chloronaphthalen-1-yl)-N6-(6-((6-chloronaphthalen-1-yl)amino)hexyl)-N6-methylhexane-1,6-diamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rebecca VW, et al. Cancer Discov. 2018 Nov 15. pii: CD-18-0706. doi: 10.1158/2159-8290.CD-18-0706.
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