DBCO-Amine ( DBCO amine )

Catalog No. M11043 CAS No. 1255942-06-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DBCO-Amine
Note

Research use only, not for human use.
Brief Description

A simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond.
Description

A simple DBCO-containing building block used to derivatize carboxyl groups in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) with DBCO moiety through a stable amide bond; A click chemistry tool used to conjugate DBCO-PEG4-MMAF to the introduced non-natural amino acid pAMF using a noncleavable linker.
Synonyms

DBCO amine
Pathway

Antibody Drug Conjugates (ADC)
Target

ADCs Linker/Click Chemistry
Recptor

ADCs Linker/Click Chemistry
Research Area

——
Indication

——

CAS Number

1255942-06-3
Formula Weight

276.34
Molecular Formula

C18H16N2O
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(CCN)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3
Chemical Name

3-Amino-1-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1-propanone

1. Currier NV, et al. Mol Cancer Ther. 2016 Jun;15(6):1291-300.

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