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D3-βArr

CAS No. 662164-09-2

D3-βArr( NCGC00379308 )

Catalog No. M20139 CAS No. 662164-09-2

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    D3-βArr
  • Note
    Research use only, not for human use.
  • Brief Description
    D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
  • Description
    D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR) which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NCGC00379308
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    thyrotropin receptor (TSHR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    662164-09-2
  • Formula Weight
    333.43
  • Molecular Formula
    C20H23N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mg/mL (299.91 mM)
  • SMILES
    CC(Nc1nc(nc2ccccc12)N1CCNCC1)c1ccccc1
  • Chemical Name
    N-(1-Phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Neumann S et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.
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