D-Leucine( (R)-Leucine )

Catalog No. M24264 CAS No. 328-38-1

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Datasheet

HNMR

HPLC

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Product Name

D-Leucine
Note

Research use only, not for human use.
Brief Description

D-Leucine potently terminates seizures even after the onset of seizure activity.
Description

D-Leucine potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.
In Vitro

In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes.
In Vivo

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Synonyms

(R)-Leucine
Pathway

Proteasome/Ubiquitin
Target

Endogenous Metabolite
Recptor

Human Endogenous Metabolite
Research Area

——
Indication

——

CAS Number

328-38-1
Formula Weight

131.17
Molecular Formula

C6H13NO2
Purity

>98% (HPLC)
Solubility

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
SMILES

CC(C)C[C@H](C(O)=O)N
Chemical Name

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1.Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193

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