Cytisine ( Baptitoxin; Citizin; HSDB 3560; Laburnin; NSC 407282; Sophorin; Cytisine; Cytisinicline )

Catalog No. M14623 CAS No. 485-35-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Cytisine
Note

Research use only, not for human use.
Brief Description

Cytisine is an alkaloid that is found naturally in several plant genera such as Laburnum and Cytisus of the family Fabaceae.
Description

Cytisine is an alkaloid that is found naturally in several plant genera such as Laburnum and Cytisus of the family Fabaceae. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Tabex (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost.
Synonyms

Baptitoxin; Citizin; HSDB 3560; Laburnin; NSC 407282; Sophorin; Cytisine; Cytisinicline
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

nAChR
Research Area

Neurological Disease
Indication

——

CAS Number

485-35-8
Formula Weight

190.25
Molecular Formula

C11H14N2O
Purity

>98%(HPLC)
Solubility

Ethanol: 38 mg/mL (199.74 mM); Water: 38 mg/mL (199.74 mM); DMSO: 38 mg/mL (199.74 mM)
SMILES

O=C1C=CC=C2N1C[C@]3([H])CNC[C@@]2([H])C3
Chemical Name

(1R,5S)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one

1.Walker N, et al. N Engl J Med. 2014 Dec 18;371(25):2353-62.

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