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Cysmethynil

CAS No. 851636-83-4

Cysmethynil( —— )

Catalog No. M34818 CAS No. 851636-83-4

Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 59 Get Quote
5MG 85 Get Quote
10MG 136 Get Quote
25MG 266 Get Quote
50MG 426 Get Quote
100MG 671 Get Quote
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Biological Information

  • Product Name
    Cysmethynil
  • Note
    Research use only, not for human use.
  • Brief Description
    Cysmethynil is an indole-based time-dependent inhibitor of Icmt with antitumour activity and inhibitory effects on RAS membrane-binding and EGF signalling.
  • Description
    Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research.
  • In Vitro
    Cell Viability AssayCell Line:PC3 cells Concentration:20-30 μM cysmethynil Incubation Time:1-6 days Result:Resulted in a dose- and time-dependent reduction in the number of viable PC3 cells.
  • In Vivo
    Animal Model:6 week-old SCID mice with SiHa cells in the mice flank Dosage:20 mg/kg (single; combination with Paclitaxel or Doxorubicin)Administration:intraperitoneal injection; three times a week; 2 weeks Result: Decreased in tumor size when treated with Cys alone, or Cysmethynil+Paclitaxel(HY-B0015)/Cysmethynil+ Doxorubicin(HY-15142A) .Animal Model:SCID mice with PC3 cells in a xenograft model Dosage:0.1 mg/g or 0.2 mg/g Cysmethynil Administration:intraperitoneal injection; every 48 h; 28 days Result:Decreased in tumor size when treated with both doses of cysmethynil.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy | Ras
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    851636-83-4
  • Formula Weight
    376.53
  • Molecular Formula
    C25H32N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N)CC1=CN(C2=CC=C(C=C21)C=3C=CC=C(C3)C)CCCCCCCC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Winter-Vann AM, et al. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.?
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