Cyclophilin inhibitor C31( SMCypI C31 )

Catalog No. M17086 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Cyclophilin inhibitor C31
Note

Research use only, not for human use.
Brief Description

Cyclophilin inhibitor C31 (SMCypI C31) is a small-molecule cyclophilin (CypA) inhibitor (SMCypI) with PPIase inhibition IC50 of 0.1 uM.
Description

Cyclophilin inhibitor C31 (SMCypI C31) is a small-molecule cyclophilin (CypA) inhibitor (SMCypI) with PPIase inhibition IC50 of 0.1 uM, displays anti-HCV activity (HCV Gt1b replicon EC50=0.4 uM) and disrupts the CypA-NS5A interaction; exerts at least additive antiviral effects when combined with the NS5A inhibitor ledipasvir and is fully active against ledipasvir-resistant viruses; also inhibits the replication of other members of the Flaviviridae family (DENV EC50=7.3 uM), YFV EC50, 27.2 uM, and ZIKV EC50=48.0 uM), without significant cytotoxicity.
In Vitro

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In Vivo

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Synonyms

SMCypI C31
Pathway

Microbiology/Virology
Target

HCV
Recptor

HCV
Research Area

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Indication

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CAS Number

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Formula Weight

474.623
Molecular Formula

C27H30N4O2S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

1-(4-aminobenzyl)-3-(2-(2-(2-(methylthio)phenyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)urea

1. Nevers Q, et al. Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00126-18.

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