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Cyclo(RGDfK)

CAS No. 161552-3-0

Cyclo(RGDfK) ( —— )

Catalog No. M21723 CAS No. 161552-3-0

Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cyclo(RGDfK)
  • Note
    Research use only, not for human use.
  • Brief Description
    Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor.
  • Description
    Cyclo(RGDfK) is a synthetic lipopeptide inhibitor of αvβ3 integrin (IC50 = 1.33 nM).1 Osteoblast cultures, which express αvβ5 and αvβ3 integrins, but not M21L cells that do not express these integrins, bind to cyclo(RGDfK)-coated surfaces. Cyclo(RGDfK) is taken up into tumors in vivo and in vitro and it has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Integrin
  • Recptor
    αvβ3 integrin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    161552-3-0
  • Formula Weight
    717.69
  • Molecular Formula
    C29H42F3N9O9
  • Purity
    >98% (HPLC)
  • Solubility
    Water,100 mg/mL (139.34 mM)
  • SMILES
    C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O.C(=O)(C(F)(F)F)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. imeek, J., Notni, J., Kapp, T.G., et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of 68Ga-NOPO-c(RGDfK). Mol. Pharm. 11(5), 1687-1695 (2014). 2. Dijkgraaf, I., Beer, A.J., and Wester, H.-J. Application of RGD-containing peptides as imaging probes for alphavbeta3 expression. Front. Biosci. (Landmark Ed.) 14, 887-899 (2009).
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