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CyPPA

CAS No. 73029-73-9

CyPPA( —— )

Catalog No. M24739 CAS No. 73029-73-9

CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CyPPA
  • Note
    Research use only, not for human use.
  • Brief Description
    CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
  • Description
    CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
  • In Vitro
    CyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM.
  • In Vivo
    CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine| SK3| SK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    73029-73-9
  • Formula Weight
    285.39
  • Molecular Formula
    C16H23N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 99 mg/mL (346.89 mM; Need ultrasonic)
  • SMILES
    Cc1cc(C)nn1-c1nc(NC2CCCCC2)cc(C)n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Herrik KF, et al.CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Front Pharmacol. 2012 Feb 13;3:11.
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