Costunolide

Research use only, not for human use.

Costunolide has anti-inflammatory and anti-oxidant properties and mediates apoptosis.

Costunolide, also known as (+)-Costunolide, CCRIS 6754 and NSC 106404, is a naturally occurring sesquiterpene lactone, first isolated in Saussurea costus roots in 1960. It is also found in lettuce. Costunolide has been reported for the wide spectrum of biological effects, including anti-inflammatory, anticancer, antiviral, antimicrobial, antifungal, antioxidant, antidiabetic, antiulcer, and anthelmintic activities. In recent years, it have caused extensive interest in researchers due to its potential anti-cancer activities for various types of cancer, and their anti-cancer mechanisms, including causing cell cycle arrest, inducing apoptosis and differentiation, promoting the aggregation of microtubule protein, inhibiting the activity of telomerase, inhibiting metastasis and invasion, reversing multidrug resistance, restraining angiogenesis has been studied.

CCRIS 6754; NSC 106404; Costus lactone; (+)-Costunolide

Others

Other Targets

FPTase; Telomerase (MCF-7); Telomerase (MDA-MB-231)

Cancer

——

553-21-9

232.32

C15H20O2

95%

DMSO : ≥ 49 mg/mL; 210.92 mM

O1[C@H]2[C@H](C(=C)C1=O)CC/C(=C/CC/C(=C/2)/C)/C

(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one

(-20℃)

With Ice Pack

≥ 2 years