Cortisone( 17-Hydroxy-11-dehydrocorticosterone | Kendall's compound E )

Catalog No. M14883 CAS No. 53-06-5

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HPLC

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Product Name

Cortisone
Note

Research use only, not for human use.
Brief Description

Cortisone is a pregnane (21-carbon) steroid hormone, one of the main hormones released by the adrenal gland in response to stress.
Description

Cortisone is a pregnane (21-carbon) steroid hormone, one of the main hormones released by the adrenal gland in response to stress.Allergy Approved(In Vitro):Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).(In Vivo):Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.
In Vitro

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In Vivo

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Synonyms

17-Hydroxy-11-dehydrocorticosterone | Kendall's compound E
Pathway

Endocrinology/Hormones
Target

GR
Recptor

GlucocorticoidReceptor
Research Area

Inflammation/Immunology
Indication

Allergy

CAS Number

53-06-5
Formula Weight

360.444
Molecular Formula

C21H28O5
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

C[C@@]1(C2)[C@](C(CO)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])C2=O)=O
Chemical Name

Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-