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Cnidicin

CAS No. 14348-21-1

Cnidicin( —— )

Catalog No. M23598 CAS No. 14348-21-1

Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Cnidicin
  • Note
    Research use only, not for human use.
  • Brief Description
    Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM).
  • Description
    Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro .
  • In Vitro
    Cnidicin shows a significant inhibition upon the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50= 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50=7.5 μM).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    NO Synthase|NOS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    14348-21-1
  • Formula Weight
    354.4
  • Molecular Formula
    C21H22O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    CC(=CCOC1=C2C=COC2=C(C3=C1C=CC(=O)O3)OCC=C(C)C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines.Phytother Res. 2007 Mar;21(3):288-90.
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