Clofarabine ( Clolar; Evoltra )

Catalog No. M10922 CAS No. 123318-82-1

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HNMR

HPLC

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Product Name

Clofarabine
Note

Research use only, not for human use.
Brief Description

Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
Description

Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.
Synonyms

Clolar; Evoltra
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

RR
Research Area

Cancer
Indication

——

CAS Number

123318-82-1
Formula Weight

303.68
Molecular Formula

C10H11ClFN5O3
Purity

>98%(HPLC)
Solubility

DMSO: 60 mg/mL (197.57 mM)
SMILES

O[C@H]1[C@H](CO)O[C@@H](N2C=NC3=C(N)N=C(Cl)N=C23)[C@@H]1F
Chemical Name

(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol

1. Bonate PL, et al. Nat Rev Drug Discov, 2006, 5(10), 855-863.

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