Clenbuterol

Research use only, not for human use.

Clenbuterol is a substituted phenylaminoethanol that has β2 adrenomimetic properties at very low doses, and is used as a bronchodilator in asthma.

Clenbuterol is a substituted phenylaminoethanol that has β2 adrenomimetic properties at very low doses, and is used as a bronchodilator in asthma.

Clenbuterol (NAB-365) is a selective β2-adrenergic agonist (β2/β1 ratio = 4.0). Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process.Clenbuterol (10-200 μM; for 24 or 48 hours) decreases the viability of C2C12 myoblasts. Clenbuterol (100 μM) significantly decreases DNA synthesis. Clenbuterol (100 μM; for 12 h) increases the proportion of cells in G0/G1 phase. Clenbuterol treatment delays cell cycle progression. Clenbuterol (100 μM) induces cell cycle arrest, but not apoptosis, in C2C12 myoblasts. Cell Viability Assay Cell Line:C2C12 cells.Concentration:0, 10, 100, and 200 μM.Incubation Time:24 and 48 hours.Result:Treatment reduced viability of C2C12 cells for 24 and 48 h.

Treatment with Clenbuterol increases survival, rescues abnormalities in respiratory function and social recognition, and improves motor coordination in young male Mecp2-null (Mecp2?/y) mice. Clenbuterol is a bronchodilator. Clenbuterol (90 μg) is administered intratracheally to five horses. Peak serum concentrations of ～230 pg/mL are detected 10 min after administration, dropping to ～50 pg/mL within 30 min and declining much more slowly thereafter. Intratracheal administration of clenbuterol shortly before race time can be detected with this serum test. Animal Model:Male Mecp2?/y and female Mecp2?/+ mice Dosage:5 or 0.1 mg/kg.Administration:Injected i.p.; daily for 5 d, followed by a 2-d off period, repeated weekly Result:Significantly improved the phenotype during the second but not first day of testing, implying a modest effect on motor coordination in Mecp2-null mice.

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Angiogenesis

Adrenergic Receptor

β2-adrenergic receptor

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37148-27-9

277.19

C12H18Cl2N2O

>98% (HPLC)

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CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years