Cis-22a( —— )

Catalog No. M35266 CAS No. 1819366-84-1

Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Cis-22a
Note

Research use only, not for human use.
Brief Description

Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative effects on T47D human breast cancer cells.
Description

TRPV6-IN-1 is a potent and selective TRPV6 inhibitor. TRPV6-IN-1 has anti-proliferative effect and can be used for the research of cancer.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Calcium Channel
Recptor

Calcium Channel | TRP/TRPV Channel
Research Area

——
Indication

——

Chemical Information

CAS Number

1819366-84-1
Formula Weight

449.51
Molecular Formula

C24H30F3N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

C(C(O)=O)(F)(F)F.CC=1C=C([C@H]2CC[C@H](CC2)N3CCN(CC3)C=4C=CC=NC4)C=CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Simonin C, et al. Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. Angew Chem Int Ed Engl. 2015 Dec 1;54(49):14748-52.?

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