Cipargamin

Research use only, not for human use.

Cipargamin (KAE609, NITD609) is a fast-acting, potent antimalarial agent that inhibits blood-stage activity in vitro against a panel of culture-adapted P. falciparum strains with IC50 of 0.5-1.4 nM.

Cipargamin (KAE609, NITD609) is a fast-acting, potent antimalarial agent that inhibits blood-stage activity in vitro against a panel of culture-adapted P. falciparum strains with IC50 of 0.5-1.4 nM; inhibits the early and late development of Plasmodium falciparum gametocytes in vitro in a dose-dependent fashion over a range of 5 to 500 nM; also is a very effective drug in reducing transmission to the Anopheles stephensi mosquito vector; shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in rodent malaria model.Parasite Infection Phase 2 Clinical

KAE609;NITD609

Microbiology/Virology

Parasite

Parasite

Infection

Parasite Infection

1193314-23-6

390.24

C19H14Cl2FN3O

>98% (HPLC)

DMSO : 50 mg/mL 128.13 mM;H2O : < 0.1 mg/mL

O=C([C@]12N[C@@H](C)CC3=C1NC4=C3C=C(F)C(Cl)=C4)NC5=C2C=C(Cl)C=C5

(1'R,3'S)-5,7'-Dichloro-6'-fluoro-2',3',4',9'-tetrahydro-3'-methylspiro[3H-indole-3,1'-[1H]pyrido[3,4-b]indol]-2(1H)-one

(-20℃)

With Ice Pack

≥ 2 years