Chetomin ( Chetomin; CTM; NSC-289491; NSC 289491 )

Catalog No. M17999 CAS No. 1403-36-7

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Datasheet

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HPLC

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Product Name

Chetomin
Note

Research use only, not for human use.
Brief Description

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
Description

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.
Synonyms

Chetomin; CTM; NSC-289491; NSC 289491
Pathway

Others
Target

Other Targets
Recptor

HIF-1
Research Area

Cancer
Indication

——

CAS Number

1403-36-7
Formula Weight

710.87
Molecular Formula

C31H30N6O6S4
Purity

98%
Solubility

——
SMILES

CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
Chemical Name

2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione