Chetomin
CAS No. 1403-36-7
Chetomin( Chetomin | CTM | NSC-289491 | NSC 289491 )
Catalog No. M17999 CAS No. 1403-36-7
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 158 | Get Quote |
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5MG | 284 | Get Quote |
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10MG | 455 | Get Quote |
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100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameChetomin
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NoteResearch use only, not for human use.
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Brief DescriptionChetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
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DescriptionChetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.
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In VitroWestern Blot Analysis Cell Line:H460 and H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Showed progressively lower expression of several survival-promoting proteins promoted by Hsp90/HIF1α activity, including insulin-like growth factor 1 (IGF1 R), epidermal growth factor receptor (EGFR), Src, mitogen-activated protein kinase kinase 1/2 (MEK1/2), activation of protein kinase B (Akt), and mammalian target of rapamycin (mTOR).Cell Cycle Analysis Cell Line:H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Elicited cell cycle arrest in susceptible and chemoresistant NSCLC cell lines.
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In VivoAnimal Model:Mouse Dosage:0~100 mg/kg Administration:P.o.Result:Inhibited lung tumorigenesis in NSCLC mouse models.
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SynonymsChetomin | CTM | NSC-289491 | NSC 289491
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PathwayOthers
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TargetOther Targets
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RecptorHIF-1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1403-36-7
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Formula Weight710.87
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Molecular FormulaC31H30N6O6S4
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
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Chemical Name2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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