Chetomin

CAS No. 1403-36-7

Chetomin( Chetomin | CTM | NSC-289491 | NSC 289491 )

Catalog No. M17999 CAS No. 1403-36-7

Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 158 Get Quote
5MG 284 Get Quote
10MG 455 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Chetomin
  • Note
    Research use only, not for human use.
  • Brief Description
    Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
  • Description
    Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. Chetomin induces degradation of XIAP and enhances TRAIL sensitivity in urogenital cancer cells. Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma.
  • In Vitro
    Western Blot Analysis Cell Line:H460 and H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Showed progressively lower expression of several survival-promoting proteins promoted by Hsp90/HIF1α activity, including insulin-like growth factor 1 (IGF1 R), epidermal growth factor receptor (EGFR), Src, mitogen-activated protein kinase kinase 1/2 (MEK1/2), activation of protein kinase B (Akt), and mammalian target of rapamycin (mTOR).Cell Cycle Analysis Cell Line:H1299 cells Concentration:0~10 μM Incubation Time:24 hours Result:Elicited cell cycle arrest in susceptible and chemoresistant NSCLC cell lines.
  • In Vivo
    Animal Model:Mouse Dosage:0~100 mg/kg Administration:P.o.Result:Inhibited lung tumorigenesis in NSCLC mouse models.
  • Synonyms
    Chetomin | CTM | NSC-289491 | NSC 289491
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HIF-1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1403-36-7
  • Formula Weight
    710.87
  • Molecular Formula
    C31H30N6O6S4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
  • Chemical Name
    2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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