Chaetocin ( Chaetocin )

Catalog No. M18357 CAS No. 28097-03-2

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Product Name

Chaetocin
Note

Research use only, not for human use.
Brief Description

Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a and Neurospora crassa DIM5, respectively.
Description

Chaetocin is an inducer of apoptosis in human melanoma cells, generating reactive oxygen species and the intrinsic mitochondrial pathway.
Synonyms

Chaetocin
Pathway

Others
Target

Other Targets
Recptor

dSU(VAR)3-9 ; mouse G9a;Neurospora crassa DIM5
Research Area

Cancer
Indication

——

CAS Number

28097-03-2
Formula Weight

696.84
Molecular Formula

C30H28N6O6S4
Purity

98%
Solubility

DMSO : ≥ 26 mg/mL 37.31 mM; H2O : < 0.1 mg/mL
SMILES

CN1C(=O)[C@@]23C[C@]4([C@@H](N2C(=O)[C@@]1(SS3)CO)NC5=CC=CC=C54)[C@]67C[C@]89C(=O)N([C@](C(=O)N8[C@H]6NC1=CC=CC=C71)(SS9)CO)C
Chemical Name

(3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone