Ceftazidime

Research use only, not for human use.

Ceftazidime(GR20263) is an antibiotic useful for the treatment of a number of bacterial infections.

Ceftazidime(GR20263) is an antibiotic useful for the treatment of a number of bacterial infections. (In Vitro):Ceftazidime (0-8 μg/mL approximately, 24 h) displays antibacterial and anti-biofilm activities against P. aeruginosa strains.Ceftazidime (0-40 μg/mL approximately, 18-20 h) has inhibitory activities against S. maltophilia isolates.(In Vivo):Ceftazidime (2 h infusion of injection, 2 000 mg, every 8 h for 24 h) moderately reduces bacterial density in a murine thigh infection model.

Cell Viability Assay Cell Line:P. aeruginosa strains (PAO1, PA1, PA2)Concentration:0-8 μg/mL approximatelyIncubation Time:24 h Result:Displayed antibacterial and anti-biofilm activities with MIC values of 2-4 μg/mL.

Animal Model:Murine thigh infection model Dosage:2000 mg Administration:2 h infusion of injection, every 8 h for 24 h.Result:Reduced bacterial density against the isogenic NDM (New Delhi metallo-β-lactamase) strain.

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GPCR/G Protein

Antibacterial

PBPs| Peptidoglycan synthase

Infection

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72558-82-8

546.57

C22H22N6O7S2

>98% (HPLC)

Water: 396 mg/L

CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC=C4)C(=O)[O-]

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(-20℃)

With Ice Pack

≥ 2 years