Cart
sales@molnova.com
Cbz-B3A
CAS No. 1884710-81-9
Cbz-B3A( —— )
Catalog No. M33307 CAS No. 1884710-81-9
Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 164 | Get Quote |
|
| 5MG | 252 | Get Quote |
|
| 10MG | 375 | Get Quote |
|
| 25MG | 596 | Get Quote |
|
| 50MG | 819 | Get Quote |
|
| 100MG | 1098 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCbz-B3A
-
NoteResearch use only, not for human use.
-
Brief DescriptionCbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.
-
DescriptionCbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
-
In VitroCbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins. Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC50 of ~3 μM.
-
In Vivo——
-
Synonyms——
-
PathwayPI3K/Akt/mTOR signaling
-
TargetmTOR
-
RecptormTOR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1884710-81-9
-
Formula Weight706.87
-
Molecular FormulaC35H58N6O9
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 20 mg/mL (28.29 mM)
-
SMILESC(=NCCC[C@@H](C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O)NC(OC(C)(C)C)=O)(NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Coffey RT, et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem. 2016 Mar 4;291(10):5221-33.?
molnova catalog
related products
-
P-2281
P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cell function and is effective in a mouse model of human colitis.
-
ML239
ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
-
Temsirolimus
A rapamycin ester and mTOR inhibitor with biochemical IC50 of 1.74 uM.
