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Cbz-B3A
CAS No. 1884710-81-9
Cbz-B3A( —— )
Catalog No. M33307 CAS No. 1884710-81-9
Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 164 | Get Quote |
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| 5MG | 252 | Get Quote |
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| 10MG | 375 | Get Quote |
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| 25MG | 596 | Get Quote |
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| 50MG | 819 | Get Quote |
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| 100MG | 1098 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCbz-B3A
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NoteResearch use only, not for human use.
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Brief DescriptionCbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.
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DescriptionCbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).
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In VitroCbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins. Cbz-B3A decreases the incorporation of [35S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC50 of ~3 μM.
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptormTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number1884710-81-9
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Formula Weight706.87
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Molecular FormulaC35H58N6O9
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20 mg/mL (28.29 mM)
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SMILESC(=NCCC[C@@H](C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O)NC(OC(C)(C)C)=O)(NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Coffey RT, et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem. 2016 Mar 4;291(10):5221-33.?
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