Castanospermine

Research use only, not for human use.

Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.

Castanospermine is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.

Castanospermine (0.01-1000 μM, 48 h) inhibits the production of DEN infectious virus in a dose-dependent manner and slows the electrophoretic mobility of DEN prM (a glycosylated structural protein) in BGK-21 cells.RT-PCR Cell Line:BHK-21 Concentration:100, 500 μM Incubation Time:48 h Result:Reduced marker gene expression or propagation of WNV or DEN replicons modestly by up to 20 to 40%, respectively.Had small effects on the secretion of infectious WNV or viral particles containing WNV RNA but decreased the amount of DEN viral RNA and infectious virus.

Animal Model:A/J mice model Dosage:10, 50, 250 mg/kg Administration:i.p.Result:Decreased secretion and virus infectivity, and increased survival rate of mice infected with DEN virus.Animal Model: Acute pancreatitis (AP) rat model Dosage:10, 50, 100, 200, 500 mg/kg Administration:i.p.Result:The extent and severity of the pancreatic injury were significantly decreased.Decreased the interleukin production in serum and NF-kB activation.Increased the level of TNF-a, ICAM-1 and VCAM-1.

1,6,7,8-Tetrahydroxyoctahydroindolizine | (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine

Cytoskeleton/Cell Adhesion Molecules

Glucokinase

α-glucosidase| β-glucosidase

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79831-76-8

189.21

C8H15NO4

>98% (HPLC)

Water: 32 mg/mL (169.12 mM)

O[C@@H](CC1)[C@H]([C@H]([C@@H]2O)O)N1C[C@@H]2O

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(-20℃)

With Ice Pack

≥ 2 years