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Capsazepine

CAS No. 138977-28-3

Capsazepine ( —— )

Catalog No. M20641 CAS No. 138977-28-3

Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM).?Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel.?It is therefore considered to be a capsaicin antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Capsazepine
  • Note
    Research use only not for human use.
  • Brief Description
    Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM).?Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel.?It is therefore considered to be a capsaicin antagonist.
  • Description
    Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM).?Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel.?It is therefore considered to be a capsaicin antagonist.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPA1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    138977-28-3
  • Formula Weight
    376.9
  • Molecular Formula
    C19H21ClN2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (132.66 mM)
  • SMILES
    Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
  • Chemical Name
    N-[2-(4-Chlorophenyl)ethyl]-1345-tetrahydro-78-dihydroxy-2H-2-benzazepine-2-carbothioamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yang MH Jung SH Sethi Get al.Pleiotropic Pharmacological Actions of Capsazepine a Synthetic Analogue of Capsaicin against Various Cancers and Inflammatory Diseases[J].Molecules. 2019 Mar 12;24(5). pii: E995.
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