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Home - Products - Metabolic Enzyme/Protease - P450 - Cambinol

Cambinol

CAS No. 14513-15-6

Cambinol ( SIRT 1/2 inhibitor IV; NSC112546; NSC-112546 )

Catalog No. M17306 CAS No. 14513-15-6

Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 69 In Stock
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25MG 207 In Stock
50MG 332 In Stock
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Biological Information

  • Product Name
    Cambinol
  • Note
    Research use only, not for human use.
  • Brief Description
    Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner.
  • Description
    Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.
  • Synonyms
    SIRT 1/2 inhibitor IV; NSC112546; NSC-112546
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    SIRT1; SIRT2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    14513-15-6
  • Formula Weight
    360.09
  • Molecular Formula
    C21H16N2O2S
  • Purity
    98%
  • Solubility
    DMSO : 50 mg/mL. 138.72 mM;H2O : < 0.1 mg/mL
  • SMILES
    O=c1c(Cc2c3ccccc3ccc2O)c(c2ccccc2)[nH]c(=S)[nH]1
  • Chemical Name
    5-((2-hydroxynaphthalen-1-yl)methyl)-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lugrin J.,et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510.
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