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Cabotegravir

CAS No. 1051375-10-0

Cabotegravir( S/GSK1265744 | GSK 744 | Cabotegravir )

Catalog No. M17126 CAS No. 1051375-10-0

Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cabotegravir
  • Note
    Research use only, not for human use.
  • Brief Description
    Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
  • Description
    Cabotegravir, also known as S/GSK1265744 or GSK744, is potent HIV integrase inhibitor under development for the treatment of HIV infection. Cabotegravir has a carbamoyl pyridone structure similar to dolutegravir.
  • In Vitro
    Cell Viability Assay Cell Line:MT-4 cells Concentration:0-32 nM Incubation Time:4 or 5 days Result:Showed antiviral activity with an EC50 of 1.3 nM.
  • In Vivo
    ——
  • Synonyms
    S/GSK1265744 | GSK 744 | Cabotegravir
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    HIV integrase
  • Research Area
    Infection
  • Indication
    ——

Chemical Information

  • CAS Number
    1051375-10-0
  • Formula Weight
    405.35
  • Molecular Formula
    C19H17F2N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 12.67 mg/mL 31.26 mM;
  • SMILES
    C[C@H]1CO[C@H]2N1C(=O)c1c(c(=O)c(cn1C2)C(=O)NCc1c(cc(cc1)F)F)O
  • Chemical Name
    (3S,11aR)-N-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yoshinaga T, et al. Antimicrob Agents ChemOthers. 2015, 59(1), 397-406.
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