CaCCinh-A01 ( CaCCinh-A01; CaCC(inh)-A01, TMEM16 Blocker I )

Catalog No. M17503 CAS No. 407587-33-1

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Product Name

CaCCinh-A01
Note

Research use only, not for human use.
Brief Description

CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM).
Description

CaCCinh-A01, also known as TMEM16 Blocker I, is a TMEM16 Blocker. CaCCinh-A01 is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50 = 10 μM).
Synonyms

CaCCinh-A01; CaCC(inh)-A01, TMEM16 Blocker I
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

TMEM16A;CaCC
Research Area

——
Indication

——

CAS Number

407587-33-1
Formula Weight

347.43
Molecular Formula

C18H21NO4S
Purity

98%
Solubility

DMSO : ≥ 50 mg/mL; 143.91 mM
SMILES

CC(C)(C)C1CCC2=C(C1)SC(=C2C(=O)O)NC(=O)C3=CC=CO3
Chemical Name

6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

1.Namkung W,etal. J Biol Chem. 2011 Jan 21;286(3):2365-74.

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