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CYM50358

CAS No. 1314212-39-9

CYM50358 ( —— )

Catalog No. M28705 CAS No. 1314212-39-9

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4?with an IC50?of 25 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CYM50358
  • Note
    Research use only, not for human use.
  • Brief Description
    N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4?with an IC50?of 25 nM.
  • Description
    N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4?with an IC50?of 25 nM.(In Vitro):N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 shows less potent inhibition of S1PR1(IC50=6.4μM).N-(4-(aminomethyl)-2,6-dimethylphenyl)-5(10μM)has no effect on the collagen-induced HSP27 phosphorylation,markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PLD1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1314212-39-9
  • Formula Weight
    389.3
  • Molecular Formula
    C20H18Cl2N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009;19(7):1916-1920.
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