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CX717
CAS No. 867276-98-0
CX717( —— )
Catalog No. M35376 CAS No. 867276-98-0
CX 717 is a positive allosteric modulator of the AMPA receptor with antidepressant-like effects and potential use in adult attention deficit hyperactivity disorder (ADHD) research .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 36 | In Stock |
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| 25MG | 71 | In Stock |
|
| 50MG | 109 | In Stock |
|
| 100MG | 177 | In Stock |
|
| 200MG | 264 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCX717
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NoteResearch use only, not for human use.
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Brief DescriptionCX 717 is a positive allosteric modulator of the AMPA receptor with antidepressant-like effects and potential use in adult attention deficit hyperactivity disorder (ADHD) research .
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DescriptionCX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD).
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In Vitro——
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In VivoCX 717 (CX717; 20 mg/kg) has a rapid (30 min) but short-lasting (up to 24 h) antidepressantlike effect in the forced swim test.CX 717 also produces a rapid (up to 1 h) increase of brain-derived neurotrophic factor (BDNF) and a more sustained (up to 6 h) increase of p11. Intra-cortical infusion of CX 717 (85 mM) increases the efflux of noradrenaline, dopamine, and serotonin, but not glutamate.Animal Model:Male Sprague-Dawley rats weighing 280-350 g Dosage:20 mg/kg (administered at 1 mL/kg) Administration:Intraperitoneal (i.p.) injection Result:Evoked antidepressant-like effects (20 mg/kg, i.p.) did not alter the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and glutamate in the medial prefrontal cortex (mPFC).
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorGluR
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Research Area——
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Indication——
Chemical Information
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CAS Number867276-98-0
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Formula Weight233.23
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Molecular FormulaC11H11N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (214.39 mM; Ultrasonic (<60°C)
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SMILESO=C(N1CCOCC1)c1ccc2nonc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Linda J Porrino, et al. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. PLoS Biol. 2005 Sep;3(9):e299.?
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