CUR61414
CAS No. 334998-36-6
CUR61414 ( —— )
Catalog No. M26658 CAS No. 334998-36-6
CUR61414 is an inhibitor of cell permeable Hedgehog signaling pathway (IC50: 100-200 nM) and selectively binds to smoothened (Smo) (Ki: 44 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 61 | Get Quote |
|
5MG | 102 | Get Quote |
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10MG | 170 | Get Quote |
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25MG | 339 | Get Quote |
|
50MG | 521 | Get Quote |
|
100MG | 745 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCUR61414
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NoteResearch use only, not for human use.
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Brief DescriptionCUR61414 is an inhibitor of cell permeable Hedgehog signaling pathway (IC50: 100-200 nM) and selectively binds to smoothened (Smo) (Ki: 44 nM).
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DescriptionCUR61414 is an inhibitor of cell permeable Hedgehog signaling pathway (IC50: 100-200 nM) and selectively binds to smoothened (Smo) (Ki: 44 nM). CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells.(In Vitro):CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells.(In Vivo):CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number334998-36-6
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Formula Weight550.7
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Molecular FormulaC31H42N4O5
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Uesawa M, Muroi K, Ozawa K. Plasmapheresis-refractory transplantation-associated thrombotic microangiopathy successfully treated with pravastatin and limaprost alfadex. Ther Apher Dial. 2013 Aug;17(4):462-3.
molnova catalog
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