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CU-CPD107
CAS No. 2573912-32-8
CU-CPD107( —— )
Catalog No. M34755 CAS No. 2573912-32-8
CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 91 | Get Quote |
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| 5MG | 130 | Get Quote |
|
| 10MG | 206 | Get Quote |
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| 25MG | 365 | Get Quote |
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| 50MG | 520 | Get Quote |
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| 100MG | 714 | Get Quote |
|
| 200MG | 972 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameCU-CPD107
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NoteResearch use only, not for human use.
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Brief DescriptionCU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM).
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DescriptionCU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA.
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In VitroCU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC50 value of 13.7?μM.CU-CPD107 (0-100 μM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA.CU-CPD107 (100 μM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetTLR
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RecptorTLR
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Research Area——
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Indication——
Chemical Information
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CAS Number2573912-32-8
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Formula Weight400.25
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Molecular FormulaC16H21IN2O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(C(C)(C)O)N1C(=C(I)N=C1COCC)C2=CC=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CU-T12-9
CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).?It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems.
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Poly(I:C)
Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-like receptor- 3 (TLR3) agonist.Mixtures that included the TLR7/8 agonists R848 or CL075, combined with the poly (I:C) can produce 3-d mature dendritic cells.
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Sparstolonin B
Sparstolonin B, a selective TLR2 and TLR4 antagonist, is an isocoumarin compound isolated from the tubers of Sparganium stoloniferum and Scirpus yagara with anti-HIV, anticancer, antitumour and anti-inflammatory activities.
