CSLP37( RIPK2 inhibitor CSLP37 )

Catalog No. M13600 CAS No. 2244984-64-1

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CSLP37
Note

Research use only, not for human use.
Brief Description

CSLP37 (RIPK2 inhibitor CSLP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay.
Description

CSLP37 (RIPK2 inhibitor CSLP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling; exhibits inhibition of TNF release from RAW264.7 cells with EC50 of 12.6 nM, inhibits NF-κB reporter activity with IC50 of 22.5 nM; antagonizes NOD2 signaling by interfering with the XIAP-RIPK2 interaction, selectively inhibits NOD responses in cells (HEKBlue NOD2 IC50=26.3 nM) and displays potent activity in vivo, does not attenuates the TNF release following an unrelated pro-inflammatory stimulation mediated through TLR4 activation by LPS at 1 uM.
In Vitro

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In Vivo

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Synonyms

RIPK2 inhibitor CSLP37
Pathway

Apoptosis
Target

RIP kinase
Recptor

RIP kinase
Research Area

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Indication

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CAS Number

2244984-64-1
Formula Weight

499.605
Molecular Formula

C25H30FN5O3S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-(5-(2-amino-5-(4-(piperazin-1-yl)phenyl)pyridin-3-yl)-3-fluoro-2-methoxyphenyl)propane-1-sulfonamide

1. Hrdinka M, et al. EMBO J. 2018 Jul 19. pii: e99372.

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