CRT0273750

CAS No. 1979939-16-6

CRT0273750 ( CRT 0273750; CRT-0273750 )

Catalog No. M27971 CAS No. 1979939-16-6

CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 71 Get Quote
5MG 110 Get Quote
10MG 177 Get Quote
25MG 402 Get Quote
50MG 593 Get Quote
100MG 845 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    CRT0273750
  • Note
    Research use only, not for human use.
  • Brief Description
    CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.
  • Description
    CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.(In Vitro):CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM. CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM).(In Vivo):CRT0273750 treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively and shows a proportional increase.CRT0273750 has a moderate blood clearance, with value of 41 mL/min/kg.
  • Synonyms
    CRT 0273750; CRT-0273750
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    Cannabinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1979939-16-6
  • Formula Weight
    502.9
  • Molecular Formula
    C25H22ClF3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Everett RM, et al. Nephrotoxicity of pravadoline maleate (WIN 48098-6) in dogs: evidence of maleic acid-induced acute tubular necrosis. Fundam Appl Toxicol. 1993 Jul;21(1):59-65.
molnova catalog
related products
  • Zomepirac Sodium

    Zomepirac, formerly marketed as Zomax tablets, was associated with fatal and near-fatal anaphylactoid reactions.

  • SEP-0372814

    PDE10-IN-1 is PDE10-IN-1 inhibitor extracted from Patent WO 2013192273 A1 for treating CNS and metabolic disorders.

  • 2-(Hydroxymethyl)pyr...

    2-Pyridinylmethanol is an organic compound.