Cart
sales@molnova.com
Home - Products - Angiogenesis - PDE - CRT0273750

CRT0273750

CAS No. 1979939-16-6

CRT0273750 ( CRT 0273750; CRT-0273750 )

Catalog No. M27971 CAS No. 1979939-16-6

CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 71 Get Quote
5MG 110 Get Quote
10MG 177 Get Quote
25MG 402 Get Quote
50MG 593 Get Quote
100MG 845 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    CRT0273750
  • Note
    Research use only, not for human use.
  • Brief Description
    CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.
  • Description
    CRT0273750 regulates plasma LPA levels and is suitable for in vivo studies. CRT0273750 is an autotaxin (ATX) inhibitor with IC50 of 0.014 μM.(In Vitro):CRT0273750 is also shown to inhibit the migration of 4T1 cells with an EC50 of 0.025μM. CRT0273750 shows high potency in both the biochemical (IC50 = 0.01 μM) and plasma choline release assay(IC50 = 0.014 μM).(In Vivo):CRT0273750 treatment shows the Cmax, AUC and t1/2 values of 3.8 μM, 3.2 μM.h and 1.4 h, respectively and shows a proportional increase.CRT0273750 has a moderate blood clearance, with value of 41 mL/min/kg.
  • Synonyms
    CRT 0273750; CRT-0273750
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    Cannabinoid Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1979939-16-6
  • Formula Weight
    502.9
  • Molecular Formula
    C25H22ClF3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@H](NC(=O)CCc1nc2cccnc2n1Cc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Everett RM, et al. Nephrotoxicity of pravadoline maleate (WIN 48098-6) in dogs: evidence of maleic acid-induced acute tubular necrosis. Fundam Appl Toxicol. 1993 Jul;21(1):59-65.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AGK2

    AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.

  • HA155

    HA155 selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.

  • MBCQ

    MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins.

Sign In Join Free