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CQ211

CAS No. 2648986-65-4

CQ211( —— )

Catalog No. M35729 CAS No. 2648986-65-4

CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM, demonstrating significant proliferation inhibitory activity against various cancer cell lines in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CQ211
  • Note
    Research use only, not for human use.
  • Brief Description
    CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM, demonstrating significant proliferation inhibitory activity against various cancer cell lines in vitro.
  • Description
    CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.
  • In Vitro
    Western Blot Analysis Cell Line:MKN-1 and HT-29 cells Concentration:0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM Incubation Time:4 h Result:Suppresseed the phosphorylation of mTOR in cancer cells.
  • In Vivo
    Animal Model:Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells Dosage:25 mg/kg Administration:Intraperitoneal administration; for 18 consecutive days; once daily Result:Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2648986-65-4
  • Formula Weight
    521.49
  • Molecular Formula
    C26H22F3N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (23.97 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1C2=C(C=3C(N1)=CC=C(C3)C=4C=CC(OC)=NC4)N(N=N2)C5=CC(C(F)(F)F)=C(C=C5)N6CCNCC6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842.?
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