CPA-7 ( CPA 7;CPA7 )

Catalog No. M12586 CAS No. 16961-77-6

A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

CPA-7
Note

Research use only, not for human use.
Brief Description

A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.
Description

A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells; selectively and significantly inhibits Stat3 activation and DNA-binding activity, induces regression of colon tumors in mouse model at 5mg/kg, with the abrogation of persistent Stat3 activity in tumors.
Synonyms

CPA 7;CPA7
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

Chemical Information

CAS Number

16961-77-6
Formula Weight

381.50
Molecular Formula

Cl3H6N3O2Pt
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

Platinum, diamminetrichloronitro- (8CI)

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Turkson J, et al. Mol Cancer Ther. 2004 Dec;3(12):1533-42.
2. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69.
3. Littlefield SL, et al. Inorg Chem. 2008 Apr 7;47(7):2798-804.
4. Liang M, et al. BMC Cancer. 2016 Jul 19;16:504.

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