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Home - Products - JAK/STAT Signaling - STAT - CPA-7

CPA-7

CAS No. 16961-77-6

CPA-7( CPA 7 | CPA7 )

Catalog No. M12586 CAS No. 16961-77-6

A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CPA-7
  • Note
    Research use only, not for human use.
  • Brief Description
    A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells.
  • Description
    A platinum-containing compound that disrupts STAT3 signaling, inhibits cell growth and induces apoptosis in STAT3-activated cancer cells; selectively and significantly inhibits Stat3 activation and DNA-binding activity, induces regression of colon tumors in mouse model at 5mg/kg, with the abrogation of persistent Stat3 activity in tumors.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CPA 7 | CPA7
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    16961-77-6
  • Formula Weight
    381.501
  • Molecular Formula
    Cl3H6N3O2Pt
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Platinum, diamminetrichloronitro- (8CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Turkson J, et al. Mol Cancer Ther. 2004 Dec;3(12):1533-42. 2. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69. 3. Littlefield SL, et al. Inorg Chem. 2008 Apr 7;47(7):2798-804. 4. Liang M, et al. BMC Cancer. 2016 Jul 19;16:504.
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