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Home - Products - Chromatin/Epigenetic - COX - COX-2-IN-2

COX-2-IN-2

CAS No. 134729-13-8

COX-2-IN-2( —— )

Catalog No. M32736 CAS No. 134729-13-8

COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    COX-2-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM.
  • Description
    COX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
  • In Vitro
    COX-2-IN-2 shows no COX-1 inhibition even at 100μM.
  • In Vivo
    COX-2-IN-2 has oral ED50 values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis, respectively, and an ED30 value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    134729-13-8
  • Formula Weight
    341.36
  • Molecular Formula
    C17H12FN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(#N)C=1C=C(N(N1)C2=CC=C(F)C=C2)C3=CC=C(S(C)(=O)=O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsuji K, et al. Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives. Chem Pharm Bull (1997), 45(6), 987-995.
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