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Home - Products - Chromatin/Epigenetic - COX - COX-2-IN-1

COX-2-IN-1

CAS No. 787623-48-7

COX-2-IN-1( —— )

Catalog No. M26018 CAS No. 787623-48-7

COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    COX-2-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).
  • Description
    COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).(In Vitro):COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respectively.
  • In Vitro
    COX-2-IN-1(compound5f) is an inhibitor of COX-1 and COX-2 withIC50sof>100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    Alkyl-Chain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    787623-48-7
  • Formula Weight
    442.84
  • Molecular Formula
    C18H14ClF3N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1c[nH]c2c(Cl)cccc12)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21.
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