COH34 ( -[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol )

Catalog No. M26126 CAS No. 906439-72-3

COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

COH34
Note

Research use only, not for human use.
Brief Description

COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.
Description

COH34 is a selective inhibitor of PARG with an IC50 of 0.37 nM and a Kd of 0.547 μM. COH34 prolongs PARylation at DNA lesions and traps DNA repair factors.(In Vitro):COH34 potently inhibits PARP inhibitor-resistant cancer cells.(In Vivo):COH34 shows antitumor activity in xenograft mouse cancer models.
Synonyms

-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol
Pathway

Others
Target

Other Targets
Recptor

Cytidine deaminase
Research Area

——
Indication

——

Chemical Information

CAS Number

906439-72-3
Formula Weight

293.4
Molecular Formula

C18H15NOS
Purity

>98% (HPLC)
Solubility

——
SMILES

Cc1ccc(S\N=C\c2c(O)ccc3ccccc23)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424.

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