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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - COH-29

COH-29

CAS No. 1190932-38-7

COH-29 ( COH29;COH 29 )

Catalog No. M10655 CAS No. 1190932-38-7

A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    COH-29
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
  • Description
    A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM; overcomes hydroxyurea and gemcitabine resistance in cancer cells, effectively inhibits proliferation of most cell lines in the NCI 60 human cancer panel; inhibits nonhomologous end joining (NHEJ) efficiency in HCC1937 cells; reduced tumor growth in mouse xenograft models of human cancer.
  • Synonyms
    COH29;COH 29
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    RNR(KBcell)
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1190932-38-7
  • Formula Weight
    420.44
  • Molecular Formula
    C22H16N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    OC1=C(O)C=C(C(NC2=NC(C3=CC(O)=C(O)C=C3)=C(C4=CC=CC=C4)S2)=O)C=C1
  • Chemical Name
    Benzamide,N-[4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxy-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhou B, et al. Cancer Res. 2013 Nov 1;73(21):6484-93.
2. Chen MC, et al. Mol Pharmacol. 2015 Jun;87(6):996-1005.
3. Zhang H, et al. BMC Cancer. 2014 Sep 11;14:664.
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