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COH-29
CAS No. 1190932-38-7
COH-29 ( COH29;COH 29 )
Catalog No. M10655 CAS No. 1190932-38-7
A small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 138 | In Stock |
|
| 5MG | 309 | In Stock |
|
| 25MG | 628 | In Stock |
|
| 50MG | 897 | In Stock |
|
| 100MG | 1224 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCOH-29
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NoteResearch use only, not for human use.
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Brief DescriptionA small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM.
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DescriptionA small-molecule inhibitor of ribonucleotide reductase (RNR) that binds to RRM2, interfering with RRM1-RRM2 interactions with IC50 of 16 uM; overcomes hydroxyurea and gemcitabine resistance in cancer cells, effectively inhibits proliferation of most cell lines in the NCI 60 human cancer panel; inhibits nonhomologous end joining (NHEJ) efficiency in HCC1937 cells; reduced tumor growth in mouse xenograft models of human cancer.
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SynonymsCOH29;COH 29
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorRNR(KBcell)
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1190932-38-7
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Formula Weight420.44
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Molecular FormulaC22H16N2O5S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 31 mg/mL
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SMILESOC1=C(O)C=C(C(NC2=NC(C3=CC(O)=C(O)C=C3)=C(C4=CC=CC=C4)S2)=O)C=C1
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Chemical NameBenzamide,N-[4-(3,4-dihydroxyphenyl)-5-phenyl-2-thiazolyl]-3,4-dihydroxy-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhou B, et al. Cancer Res. 2013 Nov 1;73(21):6484-93.
2. Chen MC, et al. Mol Pharmacol. 2015 Jun;87(6):996-1005.
3. Zhang H, et al. BMC Cancer. 2014 Sep 11;14:664.
2. Chen MC, et al. Mol Pharmacol. 2015 Jun;87(6):996-1005.
3. Zhang H, et al. BMC Cancer. 2014 Sep 11;14:664.
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