CNX-1351

CAS No. 1276105-89-5

CNX-1351 ( CNX1351; CNX 1351; CNX-1351 )

Catalog No. M17234 CAS No. 1276105-89-5

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 87 In Stock
10MG 140 In Stock
25MG 266 In Stock
50MG 492 In Stock
100MG 710 In Stock
500MG 1467 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    CNX-1351
  • Note
    Research use only, not for human use.
  • Brief Description
    CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
  • Description
    CNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.
  • Synonyms
    CNX1351; CNX 1351; CNX-1351
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PI3Kα
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1276105-89-5
  • Formula Weight
    573.71
  • Molecular Formula
    C30H35N7O3S
  • Purity
    98%
  • Solubility
    DMSO : ≥ 21.8 mg/mL. 38.00 mM
  • SMILES
    C1CN(CCN1C(=O)CCC(=O)C=C(C)C)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1
  • Chemical Name
    1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21.
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