CNX-1351

CAS No. 1276105-89-5

CNX-1351 ( CNX1351; CNX 1351; CNX-1351 )

Catalog No. M17234 CAS No. 1276105-89-5

CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 87 In Stock
10MG 140 In Stock
25MG 266 In Stock
50MG 492 In Stock
100MG 710 In Stock
500MG 1467 In Stock
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Biological Information

  • Product Name
    CNX-1351
  • Note
    Research use only, not for human use.
  • Brief Description
    CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
  • Description
    CNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.
  • Synonyms
    CNX1351; CNX 1351; CNX-1351
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PI3Kα
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1276105-89-5
  • Formula Weight
    573.71
  • Molecular Formula
    C30H35N7O3S
  • Purity
    98%
  • Solubility
    DMSO : ≥ 21.8 mg/mL. 38.00 mM
  • SMILES
    C1CN(CCN1C(=O)CCC(=O)C=C(C)C)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1
  • Chemical Name
    1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21.
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