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CNX-1351
CAS No. 1276105-89-5
CNX-1351( CNX1351 | CNX 1351 | CNX-1351 )
Catalog No. M17234 CAS No. 1276105-89-5
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | In Stock |
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| 10MG | 140 | In Stock |
|
| 25MG | 266 | In Stock |
|
| 50MG | 492 | In Stock |
|
| 100MG | 710 | In Stock |
|
| 500MG | 1467 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCNX-1351
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NoteResearch use only, not for human use.
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Brief DescriptionCNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
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DescriptionCNX-1351 is a selective covalent Inhibitor of PI3Kα. In an end point assay, CNX-1351 potently inhibited PI3Kα and was 20?400 times less potent against β, γ, and δ. CNX-1351 inhibit PI3Kα signaling in cells and shows prolonged inhibition consistent with a covalent mechanism of Action. CNX-1351 inhibits growth of cells dependent on PI3Kα. CNX-1351 also inhibits PI3Kα signaling in vivo and bonds to p110α.
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In Vitro——
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In Vivo——
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SynonymsCNX1351 | CNX 1351 | CNX-1351
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PathwayOthers
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TargetOther Targets
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RecptorPI3Kα
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1276105-89-5
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Formula Weight573.71
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Molecular FormulaC30H35N7O3S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 21.8 mg/mL. 38.00 mM
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SMILESC1CN(CCN1C(=O)CCC(=O)C=C(C)C)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1
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Chemical Name1-(4-((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-6-methylhept-5-ene-1,4-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nacht M, et al. J Med Chem. 2013 Feb 14;56(3):712-21.
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