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CM11
CAS No. ——
CM11( CM-11 | CM 11 )
Catalog No. M16922 CAS No. ——
A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation; induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCM11
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NoteResearch use only, not for human use.
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Brief DescriptionA homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation; induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
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DescriptionA homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation; induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines, in a highly isoform-selective fashion and without triggering a hypoxic response; a novel chemical probe for selective VHL knockdown.
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In Vitro——
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In Vivo——
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SynonymsCM-11 | CM 11
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PathwayPROTACs
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TargetPROTAC
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RecptorPROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight1179.456
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Molecular FormulaC58H82N8O14S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)COCCOCCOCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O
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Chemical NameN1,N20-bis((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-3,6,9,12,15,18-hexaoxaicosanediamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Maniaci C, et al. Nat Commun. 2017 Oct 10;8(1):830.
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