CLK8( —— )

Catalog No. M36544 CAS No. 898920-65-5

CLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-related disorders.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

CLK8
Note

Research use only, not for human use.
Brief Description

CLK8 is a selective CLOCK inhibitor that binds to and interferes with CLOCK activity, disrupts the interaction between CLOCK and BMAL1, and modulates circadian rhythm amplitude.CLK8 can be used to study circadian rhythm-related disorders.
Description

CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms.
In Vitro

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In Vivo

Animal Model:Male C57BL/6J mice (8 weeks, 18-24 g)Dosage:25 mg/kg Administration:A single i.p.Result:A decrease in CLOCK levels was detected in whole cell lysates of the mouse livers, whereas the levels of BMAL1 and CRY1 were unaltered.Decreased the abundance of CLOCK in the nucleus.The abundances of cytosolic and nuclear BMAL1 and CRY1 were unaltered.Decreased Cry1 transcriptional level.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

898920-65-5
Formula Weight

498.53
Molecular Formula

C29H26N2O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (100.29 mM; Ultrasonic )
SMILES

O=C1OC2=C(C(OCC(=O)NC=3C=CC=CC3C(=O)N)=CC=4OC(C)(C)CCC42)C(=C1)C=5C=CC=CC5
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Doruk YU, et, al. A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J Biol Chem. 2020 Mar 13;295(11):3518-3531. ?

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