CLEFMA

CAS No. 1246964-32-8

CLEFMA( —— )

Catalog No. M28778 CAS No. 1246964-32-8

CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CLEFMA
  • Note
    Research use only, not for human use.
  • Brief Description
    CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
  • Description
    CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.(In Vitro):CLEFMA induces autophagic death in H441 cells. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.(In Vivo):Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model . In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID .
  • In Vitro
    CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity.CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively.CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells.CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells.CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.Cell Proliferation Assay Cell Line:PANC-1, MiaPaCa-2, PC-3 and H441 cells Concentration:1, 10, 25, 100 μM Incubation Time:24, 48, 72 h Result:Inhibits cells proliferation in a dose-dependent manner.
  • In Vivo
    CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model.CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue. Animal Model:Male athymic nu/nu mice (4 weeks old) are injected H441 cells Dosage:0.2, 0.4 mg/kg Administration: I.p. daily for 4 weeks Result:Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    Antibiotic
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1246964-32-8
  • Formula Weight
    442.29
  • Molecular Formula
    C23H17Cl2NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    OC(/C=C\C(N(C/C(/C1=O)=C\c(cccc2)c2Cl)C/C1=C\c(cccc1)c1Cl)=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.
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