CL097
CAS No. 1026249-18-2
CL097 ( —— )
Catalog No. M28181 CAS No. 1026249-18-2
CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 222 | Get Quote |
|
10MG | 335 | Get Quote |
|
25MG | 566 | Get Quote |
|
50MG | 806 | Get Quote |
|
100MG | 1098 | Get Quote |
|
500MG | 2205 | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameCL097
-
NoteResearch use only, not for human use.
-
Brief DescriptionCL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.
-
DescriptionCL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.(In Vitro):CL097 (0, 0.5, 2.5, 5, and 10 μg/mL) induces hyperactivation of the NADPH oxidase by stimulating the phosphorylation of p47phox on selective sites in human neutrophils. CL097 (0.1 μM) induces activation of NF-κB in TLR7-transfected HEK293 cells and at 4 μM in TLR8-transfected HEK293 cells.(In Vivo):in NOD mice, CL097 (5 mg/kg, s.c.) causes a modest specific lysis of the target peptide (~25%). However, treatment with a combination of CL097 and CD40 agonist (10 mg/kg, i.p.) results in an increase of approximately twofold in the specific lysis of the IGRP-peptide-coated targets compared with CL097 treatment alone.
-
Synonyms——
-
PathwayImmunology/Inflammation
-
TargetROS
-
Recptor5-LOX
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1026249-18-2
-
Formula Weight242.3
-
Molecular FormulaC13H14N4O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCCOCC1=NC2=C(N1)C(N)=NC1=C2C=CC=C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Shang E, et al. Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors. Bioorg Med Chem. 2014 Apr 15;22(8):2396-402.
molnova catalog
related products
-
F-1
?F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively.?F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
-
Carminic acid
Carminic acid, the well-known red dyestuff from cochineal insects (Dactylopius spp.), is a potent feeding deterrent to ants.
-
Emeramide
Emeramide is a thiol-redox antioxidant. It is also a heavy metal chelator.