CK-2127107

CAS No. 1345410-31-2

CK-2127107 ( CK-107;Reldesemtiv )

Catalog No. M11384 CAS No. 1345410-31-2

CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 357 Get Quote
10MG 530 Get Quote
25MG 851 Get Quote
50MG 1152 Get Quote
100MG 1557 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    CK-2127107
  • Note
    Research use only, not for human use.
  • Brief Description
    CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
  • Description
    CK-2127107(CK-107, Reldesemtiv)is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats.Spinal Muscular Atrophy (SMA) Phase 2 Clinical
  • Synonyms
    CK-107;Reldesemtiv
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Neurological Disease
  • Indication
    Spinal Muscular Atrophy(SMA)

Chemical Information

  • CAS Number
    1345410-31-2
  • Formula Weight
    384.39
  • Molecular Formula
    C19H18F2N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N
  • Chemical Name
    1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68.
2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.
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