CK-2127107( CK-107 | Reldesemtiv )

Catalog No. M11384 CAS No. 1345410-31-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CK-2127107
Note

Research use only, not for human use.
Brief Description

CK-2127107(CK-107, Reldesemtiv)?is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM.
Description

CK-2127107(CK-107, Reldesemtiv)?is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats.Spinal Muscular Atrophy (SMA) Phase 2 Clinical.
In Vitro

——
In Vivo

Animal Model:Female Sprague-Dawley rats (Sham and left anterior descending coronary artery (LAD) heart failure (LAD-HF)) Dosage:10 mg/kg Administration:p.o.Result:Increased performance time by approximately 150% in LAD-HF rats (116±22 versus 283±47 seconds).
Synonyms

CK-107 | Reldesemtiv
Pathway

Others
Target

Other Targets
Recptor

Other Targets
Research Area

Neurological Disease
Indication

Spinal Muscular Atrophy(SMA)

CAS Number

1345410-31-2
Formula Weight

384.391
Molecular Formula

C19H18F2N6O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (650.40 mM)
SMILES

O=C(C1=CN(C2=CN=C(NC[C@]3(C4=NC=CC=C4F)C[C@H](F)C3)N=C2)C=C1)N
Chemical Name

1-[2-({[trans-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methyl}amino)pyrimidin-5-yl]-1H-pyrrole-3-carboxamide

1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68. 2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.

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