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CJ-42794
CAS No. 847728-01-2
CJ-42794 ( CJ-042794 )
Catalog No. M26652 CAS No. 847728-01-2
CJ-42794 is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5).
Purity : >98% (HPLC)
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Size | Price / USD | Stock | Quantity |
5MG | 29 | Get Quote |
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10MG | 45 | Get Quote |
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25MG | 88 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameCJ-42794
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NoteResearch use only, not for human use.
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Brief DescriptionCJ-42794 is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5).
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DescriptionCJ-42794 is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3) (IC50 : 8.5 (pKi )).(In Vitro):EP4 in vitro: CJ-042794 competitively inhibits PGE2-evoked elevations of intracellular cAMP levels in HEK293 cells overexpressing human EP4receptor with a mean pA2 value of 8.6. CJ-042794 reverses the inhibitory effects of PGE2 on LPS-induced TNFα production in a concentration-dependent manner. (In Vivo):CJ-42794 significantly delays the ulcer healing in rats and mice and these responses were both attenuated by coadministration of CJ-42794.
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SynonymsCJ-042794
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PathwayOthers
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TargetOther Targets
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Recptorhuman D2 receptor; human D3 receptor; human D4 receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number847728-01-2
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Formula Weight413.8
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Molecular FormulaC22H17ClFNO4
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@H](NC(=O)c1cc(Cl)ccc1Oc1ccc(F)cc1)c1ccc(cc1)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bristow LJ, et al. Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist. Trends Pharmacol Sci. 1997 Jun;18(6):186-8.
molnova catalog
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