CINPA1

CAS No. 102636-74-8

CINPA1 ( CINPA 1; CINPA-1 )

Catalog No. M26650 CAS No. 102636-74-8

CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CINPA1
  • Note
    Research use only, not for human use.
  • Brief Description
    CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.
  • Description
    CINPA1 is a selective inhibitor of constitutive androstane receptor (CAR) with an IC50 of 70 nM for CAR-mediated transcription. CINPA1 can be used in studies about CAR function.(In Vitro):CINPA1 is a specific xenobiotic receptor inhibitor and has no cytotoxic effects up to 30 μM. CINPA1 inhibits CAR-mediated gene expression in primary human hepatocytes, where CAR is endogenously expressed and it efficiently inhibits CAR-LBD interaction with the coactivator peptide. CINPA1 (1μM) inhibits CAR-mediated transactivation without activating the pregnane X receptor (PXR) in HepG2 cells. In mammalian two-hybrid assays, CINPA1 increases the corepressor and reduces coactivator interaction with the CAR ligand-binding domain. In chromatin immunoprecipitation assays, CINPA1 disrupts CAR binding to the promoter regions of target genes.
  • Synonyms
    CINPA 1; CINPA-1
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AMPAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    102636-74-8
  • Formula Weight
    395.5
  • Molecular Formula
    C23H29N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCOC(=O)Nc1ccc2CCc3ccccc3N(C(=O)CN(CC)CC)c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Rembach A, et al. Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS. J Neurosci Res. 2004 Aug 15;77(4):573-82.
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