CHIR-98014

CAS No. 252935-94-7

CHIR-98014( CHIR98014 | CHIR 98014 )

Catalog No. M13748 CAS No. 252935-94-7

CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 61 In Stock
10MG 98 In Stock
25MG 205 In Stock
50MG 335 In Stock
100MG 537 In Stock
500MG 1134 In Stock
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Biological Information

  • Product Name
    CHIR-98014
  • Note
    Research use only, not for human use.
  • Brief Description
    CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.
  • Description
    CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively; reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021; significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CHIR98014 | CHIR 98014
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    bFGFR|c-Src|GSK-3α|GSK-3β|p70S6K
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    252935-94-7
  • Formula Weight
    486.3141
  • Molecular Formula
    C20H17Cl2N9O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 11 mg/mL
  • SMILES
    NC1=C(C=CC(NCCNC2=NC=C(N3C=CN=C3)C(=N2)C2=C(Cl)C=C(Cl)C=C2)=N1)[N+]([O-])=O
  • Chemical Name
    2,6-Pyridinediamine, N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95. 2. Lian X, et al. Cell Reports. 2015 Jan 13;4(1):170.
molnova catalog
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