CHF5074

CAS No. 749269-83-8

CHF5074 ( CHF-5074; CHF5074; CHF 5074; CSP-1103 )

Catalog No. M17588 CAS No. 749269-83-8

CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 40 In Stock
5MG 65 In Stock
10MG 102 In Stock
25MG 205 In Stock
50MG 327 In Stock
100MG 492 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    CHF5074
  • Note
    Research use only, not for human use.
  • Brief Description
    CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
  • Description
    CHF-5074, also known as CSP-1103, is a γ-secretase modulator. CHF-5074 reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM respectively. CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease.
  • Synonyms
    CHF-5074; CHF5074; CHF 5074; CSP-1103
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    Beta Amyloid; γ secretase
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    749269-83-8
  • Formula Weight
    325.16
  • Molecular Formula
    C16H11Cl2FO2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 37 mg/mL; 113.79 mM
  • SMILES
    Clc1cc(c2c(F)cc(C3(CC3)C(=O)O)cc2)ccc1Cl
  • Chemical Name
    1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.
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