CHF5074
CAS No. 749269-83-8
CHF5074 ( CHF-5074; CHF5074; CHF 5074; CSP-1103 )
Catalog No. M17588 CAS No. 749269-83-8
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 40 | In Stock |
|
5MG | 65 | In Stock |
|
10MG | 102 | In Stock |
|
25MG | 205 | In Stock |
|
50MG | 327 | In Stock |
|
100MG | 492 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCHF5074
-
NoteResearch use only, not for human use.
-
Brief DescriptionCHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
-
DescriptionCHF-5074, also known as CSP-1103, is a γ-secretase modulator. CHF-5074 reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM respectively. CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease.
-
SynonymsCHF-5074; CHF5074; CHF 5074; CSP-1103
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorBeta Amyloid; γ secretase
-
Research AreaNeurological Disease
-
Indication——
Chemical Information
-
CAS Number749269-83-8
-
Formula Weight325.16
-
Molecular FormulaC16H11Cl2FO2
-
Purity98%
-
SolubilityDMSO : ≥ 37 mg/mL; 113.79 mM
-
SMILESClc1cc(c2c(F)cc(C3(CC3)C(=O)O)cc2)ccc1Cl
-
Chemical Name1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.
molnova catalog
related products
-
EGFR-IN-5
EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively.
-
HER2/neu (654-662) G...
Affibody (affibody) ligands that are specific for the extracellular domain of human epidermal growth factor receptor 2 (HER2/neu) have been selected by phage display technology from a combinatorial protein library based on the 58 amino acid residue staphylococcal protein A-derived Z domain.
-
PD173074
PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM in cell-free assays, ~1000-fold selective for FGFR1 than PDGFR and c-Src.