CHF5074 ( CHF-5074; CHF5074; CHF 5074; CSP-1103 )

Catalog No. M17588 CAS No. 749269-83-8

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Product Name

CHF5074
Note

Research use only, not for human use.
Brief Description

CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Description

CHF-5074, also known as CSP-1103, is a γ-secretase modulator. CHF-5074 reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM respectively. CHF5074 reduces brain beta-Amyloid pathology in a transgenic mouse model of Alzheimer's Disease without causing peripheral toxicity. CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease.
Synonyms

CHF-5074; CHF5074; CHF 5074; CSP-1103
Pathway

Angiogenesis
Target

EGFR
Recptor

Beta Amyloid; γ secretase
Research Area

Neurological Disease
Indication

——

CAS Number

749269-83-8
Formula Weight

325.16
Molecular Formula

C16H11Cl2FO2
Purity

98%
Solubility

DMSO : ≥ 37 mg/mL; 113.79 mM
SMILES

Clc1cc(c2c(F)cc(C3(CC3)C(=O)O)cc2)ccc1Cl
Chemical Name

1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid

1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.

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