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CGP52411
CAS No. 145915-58-8
CGP52411 ( DAPH )
Catalog No. M26105 CAS No. 145915-58-8
CGP52411 (DAPH) is a highly selective, orally active, and ATP-competitive EGFR inhibitor (IC50: 0.3 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 147 | Get Quote |
|
| 10MG | 237 | Get Quote |
|
| 25MG | 475 | Get Quote |
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| 50MG | 692 | Get Quote |
|
| 100MG | 972 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCGP52411
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NoteResearch use only, not for human use.
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Brief DescriptionCGP52411 (DAPH) is a highly selective, orally active, and ATP-competitive EGFR inhibitor (IC50: 0.3 μM).
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DescriptionCGP52411 (DAPH) is a highly selective, orally active, and ATP-competitive EGFR inhibitor (IC50: 0.3 μM). It blocks the toxic influx of Ca2+ ions into neuronal cells and dramatically inhibits and reverses the formation of β-amyloid (Aβ42) fibril aggregates.(In Vitro):In A431 cells, CGP52411 (0-100 μM) dose-dependently inhibits autophosphorylation and c-src autophosphorylation with IC50s of 1 μM and 16 μM, respectively. CGP52411 reduces tyrosine phosphorylation of p185c-erbB2 in a concentration-dependent manner(IC50 = 10 μM).CGP52411 inhibits c-src kinase (IC50 = 16 μM) and PKC isozymes isolated from porcine brain (IC50 = 80 μM).(In Vivo):In female BALB/c nude mice, CGP52411 (6.3 mg/kg-50 mg/kg; orally) shows antitumor efficacy.
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SynonymsDAPH
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PathwayOthers
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TargetOther Targets
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RecptorNon-cleavable
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Research Area——
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Indication——
Chemical Information
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CAS Number145915-58-8
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Formula Weight329.4
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Molecular FormulaC20H15N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1NC(=O)c2cc(Nc3ccccc3)c(Nc3ccccc3)cc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. J Med Chem. 2017 Dec 14;60(23):9490-9507.
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